Chronic lung disease and inflammation often go hand-in-hand, but how does inflammation impact lung repair? Antonella Dost, former Postdoc in the Clevers group, developed a human organoid model that mimics lung air sacs. Surprisingly, specific immune signals both help and hinder lung regeneration.
Hubrecht Institute
Interferon‑γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model
– @antonelladost.bsky.social et al @thecleverslab.bsky.social describe a reductionist platform for discovering strategies to enhance alveolar regeneration
link.springer.com/article/10.1...
Disease of the lung alveoli is frequently associated with acute or chronic inflammation. At present, there are no effective therapies to support regeneration of the alveolar epithelium, and ongoing in...
