Non-for-profit publication of research in molecular, cell & organismal biology - as part of @embopress.org
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The EMBO Journal
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CapK is a bacterial DNA damage-activated kinase that phosphorylates transcriptional repressor CapS to control adjacently-encoded anti-phage immune pathway genes in response to a universal stress signal, DNA damage
@kevincorbett.bsky.social and colleagues
link.springer.com/article/10.1...
Human immunosuppressive neutrophils: recent answers to old and new questions
New Perspective Article by Patrizia Scapini, Marco Cassatella et al
link.springer.com/article/10.1...
Issue 11
Highlight: Clean AIFM1 cut by OMA1 curtails respiration
Review: Antibiotic-induced gut microbiome dysbiosis
Peroxisome ether lipids & lysosomal exocytosis
Substrate allostery rules prothrombinase processivity
De nove piRNA immunity upon retrovirus insertion
link.springer.com/journal/4431...
GBP1 recruitment to actin-rich pedestals of extracellular Gram-negative bacteria promotes pyroptosis
@avishenoy.bsky.social and colleagues
link.springer.com/article/10.1...
Molecular architecture of OXGR1 reveals an evolutionary conserved mechanisms for metabolite surveillance
Xinyue Zhang et al
link.springer.com/article/10.1...
MORC3 represses a tandem repeat enhancer to regulate interferon
Moritz M Gaidt and coworkers
link.springer.com/article/10.1...
Apolipoprotein D neofunctionalization couples lipid allocation to wing evolution
Huabing Wang and coworkers provide insight into the profound metabolic innovations that were required for evolution of insect wings
link.springer.com/article/10.1...
How do cells control formation of Golgi stacks upon demand?
Roman Polishchuk, Franck Perez and collaborators identify a ‘Golgi regulon’ under control of the CREB3L1 transcription factor
link.springer.com/article/10.1...
Happy Sunday! Here comes another great week for germ cells biology!
Here @diegosainzdelamaza.bsky.social and Marc Amoyel
describe how somatic cells feed germ cells: pubmed.ncbi.nlm.nih.gov/42243520/
Read the full issue with more exciting papers here: biomed.news/bims-cebooc/...
🧪 (1/5) So proud to say that our paper was finally published in EMBO @embojournal.org. This project was a huge effort from all involved (Sarah C, the boss, and Laura M, joint first author with me). We worked on a VERY interesting system, I'll explain 👇
#science
link.springer.com/article/10.1...
The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...
The antiviral protein MORC3 is frequently inhibited by viruses. To counteract viral antagonism, MORC3 represses a noncanonical pathway of type-I-interferon (IFN) such that viral inhibition of MORC3 tr...
link.springer.com
Bacteria encode numerous stress-response pathways that protect their hosts against both internal and external threats. A key question is how these pathways are regulated, especially anti-phage immune ...
The ability of cells to sense and respond to metabolic signals is fundamental to life, yet the molecular mechanisms underlying metabolite surveillance remain incompletely understood. Here, we elucidat...
The origin of insect wings marked a pivotal evolutionary innovation that enabled their extraordinary ecological success, yet the metabolic mechanisms sustaining this transition remain elusive. Here, w...
The IFNγ-induced GTPase guanylate-binding protein 1 (GBP1) binds to lipopolysaccharide (LPS) on cytosolic gram-negative bacteria and promotes pyroptosis via the recruitment and activation of caspase-4...
Type VI secretion systems (T6SSs) are nanomachineries used by bacteria to inject toxic effectors into neighbouring cells during interbacterial competition or infection. Distinct paralogues of the stru...
