Similarly, raster photostimulation could be used at a much smaller scale to target individual dendrites or groups of dendrites of a single neuron. 5/n
My travel to Cosyne was barred by the Trump admin, so I'm here on my personal dime. I care about the COSYNE community, I committed to co-chairing. And I always learn here.
But the worst part about this travel ban is my lab colleagues— students and fellows—couldn't come. /1
While there are tradeoffs to using raster photostim (e.g. no simultaneous activation like holo photostim), we hope this tool helps to simplify and increase access for others wanting to do all-optical experiments, especially at a large-scale/across different brain regions! 7/n
Huge thanks to all involved, including @ Janelia (jET/Vivarium/MolGen/Viral Tools), MBF, and our collaborators for the amazing viruses/mice! @sverregr.bsky.social, @klensj.bsky.social, @mariannefyhn.bsky.social, Tony Drinnenberg, Charu Ramakrishnan, @deisseroth.bsky.social, and those at Allen /end
1/ 🚨🚨Preprint alert!
"Perfect" isn't always smart 🧠. Anyone can tell apart two stimuli (including our mice). But how do we extract rules that apply to new stimuli? 🧵
biorxiv.org/content/10.6...
@marius10p.bsky.social @computingnature.bsky.social
#neuroAI #neuroscience #AI
We were driven by a desire to easily ⚡️ large groups of neurons to study computations requiring coordinated activity across the 🧠
Tools exist to photostim select patterns of neurons, e.g. holographic stim, but these can be a bit restrictive; both in # of neurons, but also in setup/maintenance. 2/n
🚨 Ever wanted a simple way to control the activity of thousands of neurons? We introduce an all-optical raster photostimulation method to do just that! w/ @computingnature.bsky.social @marius10p.bsky.social #FluorescenceFriday #neuroskyence
www.biorxiv.org/content/10.6... 1/n