Father, husband, scientist, professor, martial artist, scuba diver (in about that order).
John Quackenbush
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@joshuaholland.bsky.social, even cooler is the "Wall of Hammerheads" (with a Galapagos shark along the bottom and a few Silky sharks barely visible in the distance). Shot from ~30m/100ft below the surface at Wolf Island in the Galapagos.
As the US spends >$1B per day on Trump's war in Iran, and following on the devastation of US science wreaked by the DOGE bros, other countries are making substantial investments in science in ways that will help them lead in inventing the future. www.nature.com/articles/d41...
One of the people in the DOGE braintrust who made the executive decisions to terminate federally funded research programs. A person who can't articulate what "DEI" is killed research programs, including our work to develop methods to better understand why diseases differ between men and women.
A second email, this with a more substantial insight about "The Replication Crisis"...
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I caught Covid and am working from home, perplexing our two cats. One comes to the door of the "office," sits outside, cries, is let in, and settles next to the desk. Then the other one repeats the process, causing the other cat to leave. I believe I have evidence of the Paw-li exclusion principle.
We view science as hypothesis testing, but where do hypotheses originate? From observing associations in systems we study—whether to fill known gaps or reveal the unexpected. SEAHORSE engineers serendipity—finding unexpected associations, beginning with GTEx and TCGA.
www.biorxiv.org/content/10.1...
After a long journey, a paper by my colleagues @maudfagny.bsky.social, John Platig, and Katherine Stone was published today. It builds on our earlier work in eQTL networks and casts polygenic trait selection in the context of regulatory network models, shedding new light on the process. Take a look!
This is a nice overview of both my work and the impact of federal research cuts. I am at the point where I need to think about reinventing myself because we are watching the destruction of the research enterprise in the US.
hsph.harvard.edu/news/how-doe...
The irrationality of the war on science that the Trump Administration has been waging manifests as indiscriminate termination of individual projects and whole lines of inquiry based solely on "bad words" appearing in their descriptions. #WarOnScience @statnews.com
www.statnews.com/2025/04/23/u...
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Funding for national laboratories and important research projects would increase under the government’s plans.
Large-scale, open-access data sets such as the Genotype Tissue Expression Project (GTEx) and The Cancer Genome Atlas (TCGA) include multi-omic data on large numbers of samples along with extensive cli...
www.biorxiv.org
John Quackenbush does groundbreaking research that uses massive gene datasets to explore how diseases progress, particularly cancer.
The Trump administration seems to believe that some words and ideas fail an ill-posed and completely nonscientific test of orthodoxy.
www.statnews.com
John Quackenbush
John Quackenbush
John Quackenbush
John Quackenbush
Jeremy Berg
John Quackenbush
John Quackenbush
John Quackenbush
John Quackenbush
It's stunning how ignorant the DOGE bros were who were sent into agencies. Justin Fox cannot even articulate in his own words what his "present understanding of DEI" is: he can't even formulate a coherent sentence about it. I wouldn't hire him for basic tech support. #NEH
youtu.be/jomaMvItnew?...
I’m happy to share our new paper, just published in @molbioevol.bsky.social , that shows how complex traits heritability and adaptation is supported by mutations holding key local hubs positions in eQTL networks !
doi.org/10.1093/molb...
@ideevl.bsky.social
@johnquackenbush.bsky.social
I’m sure there are things that are cooler than a school of hammerheads but can’t think of any off the top of my head. 🤿 🦑
Abstract. Complex traits are determined by many loci—mostly regulatory elements—that, through combinatorial interactions, can affect multiple traits. Such
