Happy holidays from the Helgason Lab. Wishing everyone has a wonderful festive break 🎄🎅🤶
Hot off the press from @helgasonlab.bsky.social ashpublications.org/blood/articl...
In this work we describe the development of new cell culture medium (CSFmax) that recapitulates the unique metabolite composition of the cerebrospinal fluid (CSF).
We also reveal that autophagy in critical for metabolic adaptation and survival of CNS-resident ALL cells.
Many thanks and congratulations to Katerina Himonas
for driving this work.
For those who are interested in using CSFmax in their research, the bespoke medium will be available at cancertools.org/cell-culture...
Research is never a solo effort.
It takes teamwork. It takes belief. It takes collaboration across disciplines, institutions, and communities.
We know what it takes to beat blood cancer.
#BloodCancerAwarenessMonth
Great to see this out!
authors.elsevier.com/sd/article/S...
Pleased to see it being selected as a "Plenary Paper"
Congrats again to Ekaterini Himonas and Lucie de Beauchamp - thanks to all collaborators and funders.
Thanks for Comentary by @nickvangastel.bsky.social
doi.org/10.1182/bloo...
Many thanks to funders including @cancerresearchuk.org @bloodcanceruk.bsky.social @cclguk.bsky.social
and The Howat Foundation that supported this work.
Thanks to all the local colleagues at
@uofgcancersciences.bsky.social @glasgow.ac.uk @cruk-si.bsky.social and international collaborators who played an essential role in this work!
And many thanks to funders including
@bloodcanceruk.bsky.social and @cancerresearchuk.org
#BloodCancerResearch
Delighted to share our publication in
@bloodjournal.bsky.social where we describe the identification of antifungal itraconazole as a potent inhibitor of mitochondrial metabolism in AML
Great effort by joint first authors Katerina Himonas and Lucie de Beauchamp.
ashpublications.org/blood/articl...
Delighted to share our manuscript "Physiological cerebrospinal fluid like medium reveals autophagy dependency of leukaemia in the central nervous system"
Great collaborative team effort with @chrishalsey.bsky.social and Saverio Tardito
www.biorxiv.org/content/10.6...
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Key Points. Nutrient sensing drug-repurposing screen identifies itraconazole, an FDA-approved azole antifungal, as a mitochondrial metabolism inhibitorItra
