New review: Kell, D. B. and Roberts, I. (2026) How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution. Chem Soc Rev, in press. doi.org/10.1039/d5cs... @livuni-ismib.bsky.social
Interesting, but not something that lit up in e.g. institute-genetics-cancer.ed.ac.uk/decodeme so I'd say this is not at all a unitary cause...
If folk are interested, I am giving a @BiochemSoc talk on our work with @resiapretorius.bsky.social on Fibrinaloid Microclot Complexes in Long Covid and ME/CFS on June 17 at 2pm. Registration needed but free register.gotowebinar.com/register/226... #TeamClots #pwLC #pwME
From dirt to discovery!
In our latest blog, Dr Rachel Floyd and Dr Amy Wedley discuss how research-connected teaching can build the skills, confidence and scientific curiosity the next generation of bioscientists need.
🔗 bit.ly/43avzwV
#TeamLivUni
A SECOND review with @resiapretorius.bsky.social also published today Kell, D. B. and Pretorius, E. (2026) Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging. J Biophotonics. 19, e70270. doi.org/10.1002/jbio... #TeamClots @livuni-ismib.bsky.social
Links at dbkgroup.org/longcovid/. One paper might be Kell, D. B., Laubscher, G. J. and Pretorius, E. (2022) A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications. Biochem J. 479, 537-559. doi.org/10.1042/BCJ2...
New review with @resiapretorius.bsky.social Kell, D. B., Zhao, H. and Pretorius, E. (2026) Fibrinaloid Microclots-Induced Microcirculation Dysfunction: Mechanism and Laser-Based Haemodynamic Validation. Cardiovasc Sci. 3, 10005. doi.org/10.70322/cvs... #TeamClots @livuni-ismib.bsky.social
What great presentations and illustrative slides. What a valuable discussion!
Thank you to panelists @resiapretorius.bsky.social @dbkell.bsky.social Jordan Vaughn and Jill Schofield.
We'll post recording link soon.
We were about to wrap at 2 hr 50 min when webinar accidentally ended. Sorry.
I love that the paper mentions PPAR agonists!
Maybe we'll hear more at Roundtable with @dbkell.bsky.social & @resiapretorius.bsky.social (+ Dr. Vaughn + Dr. Schofield) + some very awesome panelists.
Fri MAR 13 1 pm EDT US by @renegaderesearch.bsky.social
us06web.zoom.us/webinar/regi...
March 13 at 1 pm ET (US) for a Research Roundtable with
@resiapretorius.bsky.social of @livunipress.bsky.social @dbkell.bsky.social @jfvaughnmd09
discussing: Hypercoagulability, Clotting and Microclotting, and Blood Issues in ME/CFS and Long Covid
👇
youtu.be/FygtEROEqXE?...
register.gotowebinar.com
DecodeME aimed to find genetic causes of why people become ill with Myalgic Encephalomyelitis (ME) / Chronic Fatigue Syndrome (CFS). The study will help us understand the disease and ultimately find t...
The number of possible variants representing the landscape of a protein sequence of length N residues, made of the standard unmodified proteinogenic amino acids, is 20N; its exhaustive experimental an...
doi.org
We review the techniques of thermal imaging for assessing the functional consequences of lowered blood flow in the microcirculation that accompanies many chronic, inflammatory diseases. A comparison ...
The microcirculation typically refers to those
capillaries less than 100 μm in diameter. We have shown
that blood can clot into an anomalous amyloid form, manifesting as microclots
of typically 2–200 ...
A panel of clinicians and researchers will speak, followed by a Q&A and discussion.
Your panel:
Resia Pretorius, PhD - resiapretorius.net
Distinguished Research Prof. of Physiological Sciences
Ste...
us06web.zoom.us
🤜❤️🔥🤛 Challenger 🧪 Sourcecontrol.bsky.social. 🦋
Join us March 13 at 1 pm ET (US) for a Research Roundtable with @resiapretorius.bsky.social of @suhealthsci.bsky.social @liverpooluni.bsky.social, @dbkell.bsky.social of @liverpooluni.bsky.social, Jordan Vaughn of MedHelp, Jill Schofield of @cuanschutz.bsky.social
🧵Registration link, research below
One year ago this excellent paper was published
Myalgic Encephalomyelitis/
Chronic Fatigue Syndrome: the
biology of a neglected disease
Hayley E. Arron, Benjamin D. Marsh,
Douglas B. Kell, M. Asad Khan and Etheresia Pretorius www.frontiersin.org/journals/imm... #ME/CFS @resiapretorius.bsky.social
