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IMB Mainz, Germany RNA; Small RNAs; Germ cells; Transposons; Germ granules; nematodes; zebrafish Posts reflect my personal opinion

René Ketting

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

New paper in Genes & Dev: we dissected how Sox2 — a key pluripotency TF — is regulated by a distal enhancer cluster (SCR) 100 kb away. The results challenge simple models of cohesin-mediated loop extrusion of gene regulation. genesdev.cshlp.org/content/earl... 🧵

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A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer

genesdev.cshlp.org

www.biorxiv.org

Germ cells have their own versions of core transcription factors and fertility depends on them. We're hiring a PhD student to figure out how! 📢 Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 Deadline May 1 👇 Please share with anyone who might be interested!

Thank you @impvienna.bsky.social for featuring our next career step! The support that Ulrich @hohmannulrich.bsky.social and I received from our postdoc labs (@pauligroup.bsky.social, @juliusbrennecke.bsky.social and @plaschkalab.bsky.social), and now from @imbmainz.bsky.social has been key!

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

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Want to map protein-RNA interactions? Check out our new iCLIP3 protocol. Featuring steamlined library prep and visualisation of protein-RNA complexes without radioactivity! Bioinformatics workflow on top :) With the Müller-McNicoll and Zarnack labs! @zarnack-group.bsky.social @mixmue.bsky.social

Elzo de Wit lab @ NKI

Chromosomen, DNA, Sex und Stille Bedrohungen für unsere Spezies🧬👩🏼‍🔬👨‍🔬 Alles dies bei der #pint26de Veranstaltung am 18. Mai 📍Aposto 🕤18 Uhr Komm vorbei und lernt Annika und @reneketting.bsky.social kennen! Karten🎟👉 www.pintofscience.de/events/mainz @imbmainz.bsky.social @unimainz.bsky.social

Ulrich’s research will help advance our understanding of RNA biology & gene regulation, as well as how these mechanisms might be altered during viral infections & other diseases. @hohmannulrich.bsky.social comes from the @impvienna.bsky.social / @imbavienna.bsky.social www.imb.de/about-imb/ne...

@lorenzoorts.bsky.social previously worked as a postdoctoral fellow at @impvienna.bsky.social in Austria. She will establish a new lab at IMB to investigate how mRNA translation is activated in the early embryo. Welcome to IMB Laura! 💐 Read more here: www.imb.de/about-imb/ne...

phd.nat.au.dk

Marvin Tanenbaum

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Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.

Laura Lorenzo Orts

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Peter Andersen

König Lab

doi.org

Redirecting

Institute of Molecular Biology (IMB)

Dominik Handler

ChiaraG

Institute of Molecular Biology (IMB)

A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements https://www.biorxiv.org/content/10.64898/2026.02.07.704324v1

Securing two group leader positions at the same institute is no small feat. From IMP postdocs to group leaders: Laura Lorenzo-Orts and Ulrich Hohmann started their labs at IMB Mainz this year:

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