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Adult neurogenesis: New neurons, new opportunities
#MSCA success rates now below 10%, yet the work that goes into writing this application is immense. Beyond the obvious increase in funding we need to find ways to lighten the time investment as well. Thousands of researchers spend weeks if not months working on this.
Looking forward to trying this out!!
Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025
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Excited to share that my main PhD work with @labsalta.bsky.social is now out in @cp-cellstemcell.bsky.social ✨ — with lots of new additions! Feeling very grateful for all the teamwork and everyone who contributed along the way 💜 www.cell.com/cell-stem-ce...
Huntington’s disease is the best investment in neuroscience today www.sciencedirect.com/science/arti... #Huntingtons #Neuroscience #Investment
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
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Kempermann and colleagues discuss new directions in neuroscience stemming from an understanding that adult neurogenesis contributes to brain function in health and disease. They discuss the role and function of adult stem cells; the impact of environmental regulation; the interplay between development, plasticity, and aging; and other fundamental questions.
dlvr.it
Adult neurogenesis: New neurons, new opportunities
tinyurl.com
Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...
Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits
www.sciencedirect.com
Huntington’s disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. W…
Huntington’s disease is the best investment in neuroscience today
Tosoni and colleagues identify immature neurons in the aged human hippocampus with signatures of younger biological age and cellular fitness. Their molecular programs and intercellular interactions ar...
www.cell.com
Transcriptional profiles of immature neurons in aged human hippocampus track Alzheimer’s pathology and cognitive resilience
Giorgia Tosoni
Cell Stem Cell
Giorgia Tosoni
Poul Sørensen
🧵 1/ Excited to share our new research on immature neurons (ImN) in the adult human brain and their roles in healthy aging, Alzheimer’s disease (AD), and cognitive resilience. Here’s what we discovered 👇
Emma Dann
Jan 10, 2025
Tahnée Engelen
Jason Shepherd
Giorgia Tosoni
Let's look at some numbers 2022: 7 044 applications submitted. 17.9 % success rate 2023: 8 039 applications submitted. 15.8 % success rate 2024: 10 360 applications submitted. 16.6 % success rate 2025: 17 058 applications submitted (record high). 9.7% success rate (preliminary numbers).