Bacterial chromosome biology, gene expression, pathogenicity... and football.
www.graingerlab.com
Grainger Lab
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How are bacterial transport machineries regulated by external cues? @brochadolab.bsky.social &co identify environmental chemicals that regulate #transporter transcription, identifying the TF Rob as a key modulator of #EffluxPump expression in #Ecoli #AMR @plosbiology.org 🧪 plos.io/46pUM9Q
A busy few weeks for the lab 🥵... three new stories published. The first describes activation of transcription by DNA distortion
academic.oup.com/nar/article/...
PLOS Biology
Grainger Lab
'We show that the VqmAj homologs can indeed detect (host autoinducer) DPO and, in response, activate the lytic pathway. Our observation indicates that jVP882 is a member of a large family of globally-dispersed quorum-sensing-responsive temperate phages.'
www.biorxiv.org/content/10.1...
📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation.
www.findaphd.com/phds/?Keywor...
@danielabarilla.bsky.social kicking off #BioPhyChrom2025 - a fantastic turn out too...
Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
Two post-doctoral positions open in our lab. We're looking for people with expertise in molecular microbiology and/or genome-scale tools. Initially 3 yrs, posts could be extended for upto 8 yrs. If you'd like to know more about us take a look at www.graingerlab.com
www.jobs.ac.uk/job/DQY475/r...
In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling...
www.nature.com/articles/s41...
@ewarman.bsky.social has followed up on her discovery of bidirectional promoters in bacteria by defining their basic rules for regulation and links to gene expression noise...
academic.oup.com/nar/article/...
Grainger Lab
Explore an exciting academic career as a Research Fellow (Postdoctoral). Don't miss out on other academic jobs. Click to apply and explore more opportunities.
Abstract. Bacterial RNA polymerase binds and unwinds promoter DNA to initiate transcription. The process is often inefficient and can be stimulated by acti
Temperate phages oscillate between lysogeny, a genomic maintenance state within a bacterial host, and lytic replication, in which the host is killed, and newly made phage particles are released. Succe...
www.biorxiv.org
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
Abstract. In prokaryotes, bidirectional promoters are pseudo-symmetrical DNA sequences that stimulate divergent transcription. Ubiquitous, and far more lik
The transcription factor CarD facilitates the activation of transcription in many bacteria and in Rhodobacter sphaeroides, CarD compensates for suboptimal promoter DNA sequences. Here, the authors sho...
