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In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling... www.nature.com/articles/s41...
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www.nature.com
The transcription factor CarD facilitates the activation of transcription in many bacteria and in Rhodobacter sphaeroides, CarD compensates for suboptimal promoter DNA sequences. Here, the authors sho...
The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling - Nature Communications
Grainger Lab