Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.
rdcu.be/edRwF
Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs
Register here: tinyurl.com/mr3p49f9
Welcome to the 2025 joint “Autophagy UK and Proteostasis UK” conference!
Do you want to hear more about ubiquitin? Are you free on Friday 14:00 BST? If so, why not join the Biochemical Society early career researcher webinar series where my fellow UCL alumnus Michele Frison and I will be presenting! 💻 💡
Registration: register.gotowebinar.com/register/821...
Heatwave in London as seen from the Crick’s roof terrace at lunchtime ☀️
Fascinating and diverse programme of talks at the joint Autophagy UK and @ukproteostasis.bsky.social meeting in Dundee this week! & super happy to have the chance share our #pseudoligase work 📣
Elton Zeqiraj
Yogesh Kulathu
Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...
If you're in #immunity #cancer #neurodegeneration or #TPD fields, this might just tickle your fancy:
❓What are the biochemical functions TRIM proteins that have been implicated in these diseases?
❓What are the key catalytic features of RING domains?
❓Which TRIMs could work as #PROTAC components?
So delighted to have been part of this fantastic collaboration spearheaded by Ngee Kiat 'Jake' Chua (蔡毅杰) and Rebecca Feltham! Congratulations on bringing together so many experts in the field to make such an important resource 🎉 it has been a pleasure!
www.sciencedirect.com/science/arti...
Well put!
theguardian.com/commentisfre...
After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW
🥳 🍾 🙌
@katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk
