Brilliant findings, led by Dr Simon Cobbold, Marco Jochem and Prof David Komander (pictured L-R).
The study is also a collaboration with The University of Melbourne, University of Cologne and Alfred Health.
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I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:
We just published a commentary on Francesca Bufalieri’s new article in a Molecular Therapy that shows the power or tweaking the UPS to modulate Hedgehog signalling in cancer. With @zeqiraj.bsky.social and Kevin Shi.
authors.elsevier.com/a/1mBKX5QliS...
Our new Essays in Biochemistry review frames the DNA double strand break repair as multifunctional molecular machinery, showing how flexible our repair systems safeguard genomes from damage and help shape better cancer therapies 🧪 https://doi.org/10.1042/EBC20253043
WEHI researchers have found glycogen can be directly regulated using ubiquitin, in landmark findings published in Nature.
The study transforms understanding into glycogen metabolism & could lead to new treatments for diseases caused by abnormal sugar storage.
www.wehi.edu.au/news/sweet-d...
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My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Check out our latest paper on the ubiquitination of glycogen in cells and tissues! Congratulations to Marco Jochem (@marcojochem.bsky.social) and Simon Cobbold for leading this study and to collaborators @craigagoodman1.bsky.social, @pgregorevic.bsky.social, Kai Hofmann and Thomas Hermanns.
We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4
Preprint: www.biorxiv.org/content/10.6...
Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore
authors.elsevier.com
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.
WEHI (The Walter and Eliza Hall Institute of Medical Research)
WEHI (The Walter and Eliza Hall Institute of Medical Research)
Komander Lab
Nature Structural & Molecular Biology
Derek Lowe
Thank you @foglizzomartina.bsky.social for the nomination, and thank you to everyone for your support.
This recognition reflects the creativity and hard work of our entire team, past and present, as well as the many collaborators whose contributions make our discoveries possible.
