How do human cells defend against viruses?
@sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics
www.biorxiv.org/content/10.6...
Do you enjoy the thrill of discovery? Does this photo give you good vibes?
Then you might be the right person to join our lab!
Current projects range from chloroplast transcription to thylakoid membrane remodeling & we would be happy to welcome bright and motivated people at all career stages!
Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe.
📄 www.nature.com/articles/s41...
💾 folddisco.foldseek.com
🌐 https://search.foldseek.com/folddisco
@romihadary.bsky.social and @soreklab.bsky.social 's discovery that sponge proteins constitute enormous families of viral immune evasion factors is now out in @natmicrobiol.nature.com
@reneechang.bsky.social and our lab were happy to help with this story!
www.nature.com/articles/s41...
How do sperm and egg fuse? Surprisingly, we still don’t fully know…
Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together.
We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion.
tinyurl.com/34cm4xat
Read on! 🧵👇
Malnak, @bushmanlab.bsky.social et al. demonstrate how structural information can be used to overcome the limits of sequence-based methods and uncover fundamental principles of viral diversity and evolution.
🔗 doi.org/10.1093/molbev/msag110
#evobio #molbio #virus
New preprint! 🚨
Phage proteins don't act alone. Phages rely on homooligomerisation to assemble identical protein subunits into functional forms. But figuring out those exact configurations experimentally is tough. Learn about our approach in our new preprint! 👇 (1/n)
www.biorxiv.org/content/10.6...
A newly released AI tool has generated an atlas of more than one billion predicted protein structures and billions more protein sequences.
go.nature.com/4wS3Pen