🧬 🧪Our RNA velocity benchmark is out in PLOS Comp Biol
We tested 5 methods on mouse & zebrafish data. They often disagree (just 1/100 driver genes shared 😬). A hypothesis tool, not ground truth.
Open access 👉 doi.org/10.1371/jour...
Led by the brilliant Sarah Ancheta (not on bsky)
Sun et al, 2026. NuRD-enabled CTCF-TET crosstalk orchestrates epigenome reprogramming and genome architecture www.cell.com/molecular-ce...
Video
(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack:
Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)?
A: Transient E-P contact (~25-42 nm lasting ~10-20 sec):
www.biorxiv.org/content/10.6...
Researchers recorded from single neurons across frontotemporal cortex in 8 awake individuals during natural speech. They show how activities of collections of cells can capture syntactic & semantic properties of words, & also dynamically incorporate sentence context to encode combinatorial info.
🗣️🧠🧪
Bumble bees can apparently play with balls, count, recognize faces, & perceive rhythm. A new study out today in @science.org argues they can also solve novel tasks spontaneously without explicit training, challenging the idea that such cognitive skills are exclusive to large-brained vertebrates.😲🐝🧪👇
Wide-scale recordings reveal neurons in the human brain that encode fundamental components of language such as the grammatical relationships between words, their parts of speech and the...
Problem-solving using novel solutions without explicit training is often considered a hallmark of cognitive flexibility. We investigated whether bumble bees (Bombus terrestris) could solve a novel obj...
#Science #Biologie
🦇 « L’évolution des mécanismes du développement »
🖥️ Les vidéos du colloque organisé par le Pr @denisduboule.bsky.social, titulaire de la chaire #Évolution du développement et des #génomes, sont disponibles !
👉 https://tinyurl.com/39p4h5pn
New preprint from our lab on bioRxiv: “Stoichiometric transcription factor partnerships control GABAergic neuron fate allocation”
www.biorxiv.org/content/10.6...
A great collaboration with @annrosebright.bsky.social, Connor Lynch, @chr-mayer.bsky.social, and many others.
Very nicely done Radiolab episode featuring @emilyjacobs.bsky.social and team’s work. Check it out! radiolab.org/podcast/this...
www.biorxiv.org
Combinatorial transcription factor (TF) codes specify neuronal fates, yet how quantitative differences in interacting TFs shape these decisions remains unresolved. We address this in the developing ba...
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
