📢 @shrinivaslab.bsky.social and colleagues introduce a method for designing unstructured proteins with tunable properties. www.nature.com/articles/s43... 🖥️ 🧬
🔓 rdcu.be/eJSuV
Coupling and decoupling of the cell cycle from cell differentiation in development
In this Spotlight, @kkukreja.bsky.social & Allon Klein discuss the dependence of animal cell differentiation on cell cycle, and how their decoupling facilitates development
journals.biologists.com/dev/article-...
The authors introduce a method that combines physics and machine learning to design dynamic unstructured proteins with tunable ensemble properties like size, shape, sensing and binding.
just finished reading katalin kariko
@kkariko.bsky.social 's memoir. easily one of the most inspiring books I have read. whenever I feel down at work, face rejections or things feel unfair and hard, I can just hug the book to sleep and remind myself why we do science . . . .
Intrinsically disordered proteins (IDPs) flit between diverse shapes and interact in fuzzy ensembles whose collective properties shape function.
Q: Can we rationally design emergent properties of IDPs?
Our newest preprint takes a stab at this 🧵
biorxiv.org/content/10.6...
Ear Bending: Atlas of genes active in single cells of the developing inner ear
📷 @akankshi.bsky.social & @kkukreja.bsky.social et al @swinburnelab.bsky.social @harvardmed.bsky.social in
@elife.bsky.social
➡️ bpod.org.uk/archive/2026...
🥁We are recruiting PhD students/Postdocs with strong proven background in developmental/molecular/cell biology & related areas, for various projects- check out our lab website👇🏼
We offer: competitive stipends, super equipped lab, fun international team!
yanivelkoubylab.com
The Elkouby Lab Illuminating unpredicted cellular machineries in gonad development, germ cell production, and reproduction A Journey to Before the Beginning of Life Exploring the Unknown Developing eg...
This is my 1st publication with Development & it was such a pleasure. Nt only did reviewers provide v. constructive comments, the Editor himself (Alex Eve) also read the paper carefully & gave us very useful suggestions to improve the readability of this piece.
(2/3)
Happy to share our latest in @natcomputsci.nature.com
led by (amazing) Ryan Krueger + colab w M. Brenner!
We introduce a framework to directly design intrinsically disordered proteins (IDPs) from physics-based simulations.
🧬 doi.org/10.1038/s435...
📰 www.mccormick.northwestern.edu/news/article...
