scientist with a PhD in toxicology | views are my own
Claire McCarthy
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Nature research paper: Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
go.nature.com/4xj1VDT
Check out some cool science images (with music by @defleppard.bsky.social) from a @nature.com study. Bhargava et al. found that centromeric signatures maintain telomeric chromatin integrity in ALT cancer cells. www.nature.com/articles/s41... #FluorescenceFriday 🧪
Reading Challenge for June: post one book per day for 30 days that you’d love to see adapted to film. #booksky
7/30
en.wikipedia.org/wiki/Yestery...
Researchers have tracked the electrical crackle of individual brain cells in real time during unscripted conversations, capturing how sentences are built before a single word is spoken
go.nature.com/4v15SuB
Our genomes are full of mutations that have the potential to damage our health or even kill us. Yet most of them rarely cause problems. Why?
go.nature.com/3QuOU9B
Evidence suggests that AI-driven ‘deskilling’ is starting to happen in medicine, computer science and other fields
go.nature.com/4vtwEN1
Molecular glue degraders of the RNA-binding protein HuR have therapeutic potential for BRAF-mutant cancers.
Online Now: Context dependency in cancer neuroscience
Claire McCarthy
Claire McCarthy
Nature
Do animals perceive time differently from humans?
Science chats with @singhal.bsky.social—a researcher whose team is using “timescapes” to understand how nonhumans experience the world. https://scim.ag/4xFs4wM
A #MachineLearning model based on 11 plasma protein markers predicts the risk of #thrombosis in patients with #cancer more accurately than standard risk scores, and uncovers IL-17A as a potential therapeutic target. #ScienceTranslationalMedicine https://scim.ag/43EzHpt
A new #ScienceImmunology study demonstrates how RNA editing can destabilize or stabilize double-stranded RNA via different mechanisms, and shows that unleashing the latter can hinder tumor growth in mice. https://scim.ag/3SfLYht
Neural maps reveal the specialized cells that produce speech.
Biology has clever ways to mask the effects of potentially harmful gene mutations. Scientists are investigating how this ‘buffering’ works — and how to exploit it.
Neural signaling shapes tumor progression, but it is not intrinsically tumor-promoting or tumor-restrictive. Birbrair et al. argue that neural directionality is context-dependent and governed by tumor kinetics, tissue architecture, neural state, receptor and target-cell topology, immune-host biology, and treatment history. They propose a mechanistically interpretable and clinically actionable reporting framework for precision neuromodulatory oncology.
