Great thread! All good, but this does grab the attention:
"our findings with ΔnudJ suggest future anti-evolution drug strategies could suppress spontaneous resistance evolution not only through minimizing resistance mutations but also by specifically limiting access to the fittest mutations."
Come work/study in a wonderful department with a great group leader!!!
Come join us at UBC for all things virus-virus interactions & evolution!
@rowancallumg.bsky.social @knightjar.bsky.social @rokkrasovec.bsky.social et al. study the antimutator ΔnudJ to highlight the value of considering mutation rate and mutational spectrum to understand the evolution of mutation rate-modifying alleles.
🔗 doi.org/10.1093/molbev/msaf182
#evobio #molbio
We had two fantastic visiting speakers today
MERMan alumnus @rowancallumg.bsky.social spoke about his current work with viral cheating in influenza with @asherleeks.bsky.social
And @lavishaparab.bsky.social talked about phage infection trade-offs
Thanks to @microbesng.bsky.social for our snacks!
Finally, a shoutout to the blueycolors colour scheme for making all of my ggplots far more fun! 🟦 🟧 13/13
Deleting the nudJ gene not only makes rifampicin resistance less likely by reducing the mutation rate but also reduces the chance of a resistant mutant rising to fixation as ΔnudJ favours lower fitness mutations: synergystic effects of mutation rates and spectra impeding resistance evolution 12/13