The Woo Lab was proud to hood the three PhD’s of the class of 2026! Cheers 🥂 and congratulations 🎉 to Dr. Vanessa Dippon, Dr. Alison Mody, and Dr. Hannah Lloyd! 🫶🏼
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Another Woo Lab Dr. is in: Congrats to our newest Ph.D, Dr. Alison Mody!🫡 Cheers to a wonderful Ph.D. and a sweet (pun intended) thesis talk, all the world’s alpacas are celebrating with you in spirit 🦙🩵🟦💐🎉
We hope you all enjoyed Christina's talk as much as we enjoy sharing our science! Seems like it was a packed house 🫡
Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...
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we hope you enjoyed this paper as much as we do! 😉😘
if you’re interested in working with an allosteric ligand, reach out to Prof. Woo 🫡 we’re more than happy to share 🙌🏼🩵✨ #thefutureisallostery #CRBN #TPD
Authors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These ...
Exciting new work from @thewoolab.bsky.social just out @nature.com
www.nature.com/articles/s41...
An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.
Nature research paper: Identification of an allosteric site on the E3 ligase adapter cereblon
go.nature.com/3NHFcPj
An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.
Pour a glass of champagne AND red Bordeaux—Our newest work with GSK @scripps.edu is out in @nature.com! Here we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 www.nature.com/articles/s41...
Happy to meet Christina Woo @thewoolab.bsky.social at the meeting of the JPS meeting in Osaka. Looking forward to hearing your talk.
Carolyn Bertozzi
Nature
We are very happy that Christina Woo (@thewoolab.bsky.social) visited us for a very well-attended LED3 Lecture. She talked about the importance of C-terminal cyclic imides as natural #degrons for protein degradation with important implications for targeted protein degradation.
#TPD #ChemBio #ChemSky
