Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6...
1/9
New preprint! In an fun collaboration with @imaeso.bsky.social and @mirimiam.bsky.social led by Manu F-M, we set to explore the potential adaptation of transposable elements 👾 to host adenine DNA methylation by recruiting prokaryotic DAM methyltransferases: www.biorxiv.org/content/10.6.... 1/6
www.biorxiv.org
www.biorxiv.org
Schubeler Lab
Alex de Mendoza
Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness.
We found that transposable elements sustain stem-like states in AML and predict patient outcomes.
www.nature.com/articles/s41...
💥 Great fun writing this #review with @alejotorrescano.bsky.social
– reflecting on the emergence of #pancreatic #lineages in the #embryo through the lens of #plasticity -
Just out online ➡️ rdcu.be/fiw3c
@wellcometrust.bsky.social @kingscollegelondon.bsky.social @kingslsm.bsky.social
By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...
Nature Reviews Gastroenterology & Hepatology - Pancreatic development is a dynamic process. This Review discusses the development and cellular plasticity that occurs in the pancreas in health...
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
A week left to apply to our fully funded PhD studentship (thanks to the Generation Trust!) - entry point updated to either June or October (so no worries if you are currently finishing your MPhil!). Don't hesitate to contact me with any questions about the opportunity or the project itself.
Associate Senior Lecturer/Assistant Professor position in Molecular Microbiology available at Lund University, Sweden:
lu.varbi.com/en/what:job/...
