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We are thrilled to share our latest publication in Cell Reports (Cell Press)! A huge thank you to everyone involved in this work! šŸ“– Read the full paper here: www.cell.com/cell-reports...
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Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acid...
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
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A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
4mo
A coordinated haptic mechanism ensures efficient DNA sampling by the 8-oxoguanine glycosylase OGG1
Martinez et al. propose that OGG1 association with DNA during lesion seeking involves local DNA distortion promoting base unstacking. This process is tightly controlled by several conserved amino acids encircling the double helix, ensuring a sufficiently stable association during base interrogation while avoiding excessive engagement detrimental for fast scanning.
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Cell Reports