Fresh from science immunology, the @sancholab.bsky.social group identifies " the mitochondrial redox metabolism as a key regulator of antigen cross-presentation in conventional type 1 DCs" 👏 and 👇
www.science.org/doi/10.1126/...
Congrats to the @sancholab.bsky.social et al, for this nice paper in @natcomms.nature.com showing that "type 1 conventional dendritic cell-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...
Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
