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Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism Professor of Immunology @CNIC, Madrid, Spain. https://www.cnic.es/en/investigacion/immunobiology
David Sancho
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Congrats to the @sancholab.bsky.social et al, for this nice paper in @natcomms.nature.com showing that "type 1 conventional dendritic cell-based vaccination excels at immune memory induction and prevention of cancer recurrence" www.nature.com/articles/s41...
Fresh from science immunology, the @sancholab.bsky.social group identifies " the mitochondrial redox metabolism as a key regulator of antigen cross-presentation in conventional type 1 DCs" 👏 and 👇 www.science.org/doi/10.1126/...
7d
2d
The French DC Society - Club Francophone des DC (CFCD)
The French DC Society - Club Francophone des DC (CFCD)
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
www.nature.com
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications
Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.
Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells
www.science.org