Cats: the ultimate pets and scientific heroes. 🐱
Studying feline viruses to identify innovative solutions to prevent human infections. #preprint by @cb99-lewis.bsky.social, @dbhella.bsky.social & team #microbiology
#preLight by @orestissavva.bsky.social: prelights.biologists.com/highlights/i...
Cats: the ultimate pets and scientific heroes. Researchers are studying feline viruses to identify innovative solutions to prevent human infections
Delighted to share our article on the functional expansion of OAS2 via alt. splicing.
link.springer.com/article/10.1...
A tour de force from PhD student Emma Davies and friends.
🚨New paper!🚨
Our study showing that H5N1 influenza viruses can remain infectious in unpasteurised milk for, basically, as long as you are likely to encounter that milk has now been published:
www.microbiologyresearch.org/content/jour...
Alternative splicing broadens antiviral diversity at the human OAS2 locus
Emma Davies et al @fletcherlab.bsky.social
link.springer.com/article/10.1...
preLights
Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provi...
link.springer.com
New preprint alert! Ever wonder if cells can talk to each other? Tunneling nanotubes (TNTs) are tiny bridges between cells used to pass organelles, nucleic acids, proteins & even viruses but we've never seen inside them clearly. Until now! 👇🧵
biorxiv.org/content/10.64898/2026.05.27.728322v1
Wow - this is just amazing. Hui Guo and colleagues from John Briggs’ lab use cryoEM helical reconstruction to discover how filamentous influenza virion assembly is directed by multiple conformations of M1 - explaining how NA is concentrated at the proximal pole.
www.biorxiv.org/content/10.6...
www.biorxiv.org
The OG of outbreak viruses on cruise ships needed to remind everyone who is boss. 115 infected on the carribean princess cruise ship in an ongoing outbreak. Sounds like my idea of hell on earth. Trapped at sea on a ship full of people with vomiting and diarrhea.
abcnews.com/Internationa...
Fantastic to have this out!
As ever, I'm immensely grateful to all co-authors for their support, advice, and resource provision. This was a real collaborative effort, and highlights the potential of VP2 as a viable target for calicivirus antivirals- exciting stuff!
Fletcher Lab
Ed Hutchinson
The EMBO Journal
Eva Karasmanis
David Bhella
France confines more than 1,700 people to cruise ship over suspected norovirus death
Charlotte Lewis
www.theguardian.com
One elderly passenger on vessel docked in Bordeaux has died and about 50 people have symptoms, say officials
French authorities have confined more than 1,700 passengers and crew members on a cruise ship docked in Bordeaux after a passenger died from suspected norovirus, officials have said.
The Ambassador Cruise Line vessel carrying 1,233 passengers, most of them British or Irish, arrived in Bordeaux on Tuesday. One 90-year-old passenger had died and about 50 people had shown symptoms of the virus, French health officials said. Continue reading...
New online! Concepts of RNA virus evolution for the design of better antiviral countermeasures
dlvr.it
Nature Reviews Microbiology, Published online: 14 May 2026; doi:10.1038/s41579-026-01316-9In this Review, Tran and Vignuzzi examine how molecular processes and evolutionary pressures shape RNA virus diversity and adaptation. They outline how genome structure, mutational pathways and viral interactions influence evolutionary outcomes, offering insights relevant to the design of better vaccines and antiviral strategies.
Amazing work from Charlotte Lewis - our latest preprint describes structure guided development of an antiviral peptide, targeting VP2 portal assembly - a strategy that may have broad application to treat or prevent calicivirus disease.
www.biorxiv.org/content/10.6...
www.biorxiv.org
David Bhella
Nature Reviews Microbiology
The outbreak was reported to the CDC on Thursday, during the cruise ship's April 28 to May 11 voyage.
Interferons (IFN) are cytokines that regulate the expression of hundreds of genes during viral infections to generate a broadly antiviral environment in the stimulated cell. Antiviral breadth is provi...