SLX4IP acts as a genome-wide brake on BLM helicase activity to preserve replication fork stability under stress – both globally and at ALT telomeres
Stephanie Panier @spanier55.bsky.social, Kavi Mehta @k4v1.bsky.social and coworkers
link.springer.com/article/10.1...
Registration is open!🧬
Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers.
📅 Deadline for early registration: Jan 10, 2026
🔗 dnarepairmeeting-egmond2026.com
Faithful DNA replication is essential for genome stability, yet replication forks face constant stress. The Bloom syndrome helicase (BLM) safeguards fork integrity, but excessive BLM activity can itse...
link.springer.com
I am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌
www.cell.com/molecular-ce...
Fantastic news! 🙌 The Perutz is excited to welcome Danny Nedialkova as a new group leader starting this April! 🎉 She will strengthen the institute's research on the fundamental mechanisms that shape cellular physiology and disease ➡️ www.maxperutzlabs.ac.at/research/res...
How to keep in step when your (protein) partner speeds up…
Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.
Congrats to whole team!
www.science.org/doi/10.1126/...
Would you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679...
You'll learn a lot and it'll be fun and interesting!
#DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...
The EMBO Journal
Luijsterburglab
JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
www.nature.com/naturecareer...
Please repost!
Are you interested in working on related projects? 🌱
The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position.
Apply here: www.hubrecht.eu/jobs
Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
AmélieFT@AFTLab
Zha Lab
Video
Craig Anderson
Max Perutz Labs Vienna
Daniel Durocher
Mia Levine
The 2026 Gordon Research Conference on DNA Damage, Mutation and Cancer will be held in Ventura, California. Apply today to reserve your spot.
Using biochemical assays and a mutant disrupting RNF168-dependent ubiquitination of
the histone variant macroH2A1.2, Galloy et al. identified an unexpected role for histone
mH2A1.2 ubiquitination in p...
Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
G-quadruplexes (G4s) are prevalent DNA structures that regulate transcription but also threaten genome stability. How G4 dynamics are controlled remains poorly understood. Here, we report that RNA tra...
