Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
Thank you! It was truly a team effort. And was also inspired by some of the early works by John Dominy and Martha Stipanuk on CDO1 biology
Thank you, this could not have been done without using Rhea and Uniprot as the ground truth data. Thanks for curating and maintaining these foundational databases for biomedical research.
If you’re at #HUPO2025, be sure to stop by my poster and learn about the latest developments in the BioPlex project!
lab at Dana-Farber, Nils @nilsburger.bsky.social at UTSW, Sumeet Khetarpal at UVA, Hilina, Katherine, Eric in the Fischer lab at Dana-Farber, and Ed Huttlin @edhuttlin.bsky.social and the Gygi lab @harvardcellbio.bsky.social.