Assistant Professor at Stanford Biochemistry & Stanford Cancer Institute. We combine mass spectrometry, data science, and mechanistic biology to understand protein function and druggability. xiaolab.space
Haopeng Xiao
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Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
LRRC58 does so by serving as an E3 substrate adaptor that targets CDO1 for ubiquitylation and proteasomal degradation. We found that cysteine itself serves as a molecular signal to turn on and off LRRC58-mediated CDO1 degradation, and LRRC58 depletion stabilizes CDO1 to drive cysteine consumption.
Excited to share that I’ve started my lab as an assistant professor at the University of Texas Southwestern Medical Center in Dallas.
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
If you’re at #HUPO2025, be sure to stop by my poster and learn about the latest developments in the BioPlex project!
