Assistant Professor at Stanford Biochemistry & Stanford Cancer Institute. We combine mass spectrometry, data science, and mechanistic biology to understand protein function and druggability. xiaolab.space
Haopeng Xiao
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Thanks to all authors and collaborators that pushed this work through the finish line. A special thanks goes to Junyi and Julius in my lab @stanfordbiochem.bsky.social and @stanford-cancer.bsky.social, Mika and Milan in the Valiant lab at Stanford Computer Science, Martha, Emma, Ed in the Chouchani
lab at Dana-Farber, Nils @nilsburger.bsky.social at UTSW, Sumeet Khetarpal at UVA, Hilina, Katherine, Eric in the Fischer lab at Dana-Farber, and Ed Huttlin @edhuttlin.bsky.social and the Gygi lab @harvardcellbio.bsky.social.
LRRC58 does so by serving as an E3 substrate adaptor that targets CDO1 for ubiquitylation and proteasomal degradation. We found that cysteine itself serves as a molecular signal to turn on and off LRRC58-mediated CDO1 degradation, and LRRC58 depletion stabilizes CDO1 to drive cysteine consumption.
The results are in: top codes in Stanford #RNA 3D Folding @kaggle.com competition are competitive with CASP16-leading humans Vfold, beat AlphaFold 3. Top team’s trick was template-based modeling, not #DeepLearning. Congrats: john, odat, Eigen, + all 1706 participants! www.kaggle.com/competitions...
We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
Excited to share that I’ve started my lab as an assistant professor at the University of Texas Southwestern Medical Center in Dallas.
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
If you’re at #HUPO2025, be sure to stop by my poster and learn about the latest developments in the BioPlex project!
