Working at the interface of chemistry and biology at the University of Zurich. PI: Pablo Rivera-Fuentes
Laboratory of Chemical and Biological Probes
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Excited to share that our AzoTag paper is now out in @natchem.nature.com! 🥳
We demonstrate de novo chemo-optogenetics through the rational design of photoresponsive small molecules and selection of their artificial protein binding pairs.
www.nature.com/articles/s41...
Still obsessed with histidine (and its mimics)! Our latest work from Benjamin 🎉 uses genetic code expansion—tuning the primary coordination sphere of a dizinc metallohydrolase—lowering the catalytic pKa and boosting activity up to 5x at acidic pH. Check it out! doi.org/10.1021/acs.biochem.5c00768
They say the sincerest form of flattery is mimicry, and we really love histidine! ❤️ Check out our most recent work on histidine mimics: Genetic incorporation of diverse non-canonical amino acids for histidine substitution. www.biorxiv.org/content/10.1...
We are hiring! We have a fully funded PhD position to study how the Golgi apparatus controls its redox potential. Please apply only through the link below.
jobs.uzh.ch/job-vacancie...
Congratulations to @dorotheakossmann.bsky.social! Her paper describing a novel sensor for bacterial pH just appeared online. Great collaboration with @ayaiizuka.bsky.social and Nina Khanna within the @nccr-antiresist.bsky.social! @chem.uzh.ch
pubs.acs.org/doi/10.1021/...
Congratulations to our alumna Sarah Emmert, who received one of the GDCh Biochemistry Yound Scientist Awards! Here some of Sarah's work during her PhD at EPFL and @chem.uzh.ch: www.nature.com/articles/s41...
Now pusblished: Biopipelines! The easiest way to set up (including through vibe coding) your protein design pipelines in an HPC or Google Colab! Chek out the paper (spj.science.org/doi/abs/10.3...) and the repo: github.com/locbp-uzh/bi...
The Focus issues features views from redox biologists on the next frontiers and most needed developments in the field
www.nature.com/articles/s41...
Free to read link: rdcu.be/fbdwd
We are hiring! Excited about redox chemical biology? Help us discover what controls the redox state of the Golgi apparatus. Also, please help us spread the word by reposting this ad. Apply here: jobs.uzh.ch/job-vacancie...
Do you want to develop your own protein design pipelines using the latest tools, but do not know how to get started?
That's why GianlucaQuargnali in our lab developed BioPipelines!
Have a look at the preprint: www.biorxiv.org/content/10.6... and of course, the software: github.com/locbp-uzh/bi....
Laboratory of Chemical and Biological Probes
Shinya Tsukiji
Laboratory of Chemical and Biological Probes
Fluorescent sensors that are responsive only in a specific subcellular location have remained elusive. Now, a chemogenetic sensing platform has been developed to sense glutathione in a user-defined or...
We are excited that we could today award four Young Scientist Awards for outstanding publications and dissertations over the last two years.
The awardees are Johannes Morstein, Sarah Emmert, Frederik Schmidt and Lukas Zeisel. Congratulations to all awardees! (1/3)
#Biochemistry #ChemSky #ChemBio
We are a dynamic, interdisciplinary, medium-size lab working at the interface of chemistry and biology. We work on the development of probes to visualize and control biological processes in living sys...
jobs.uzh.ch
Optical manipulation of proteins is central to modulating and characterizing biomolecular functions in cell biology, but tools based on natural proteins are difficult to reconfigure for desired photoc...
Hydrolytic metalloenzymes employ Lewis-acidic metal cofactors to activate water molecules, generating nucleophilic hydroxide species that facilitate catalysis. Their catalytic efficiency across a wide...
We are a dynamic, interdisciplinary, medium-size lab working at the interface of chemistry and biology. We work on the development of probes to visualize and control biological processes in living sys...
