New preprint by my former colleagues in the Pauli lab 🫶 When I first joined the lab, I naively thought Bouncer’s interacting partner was a single protein. Years later, it turns out that at least 7 components on the sperm side may mediate fertilization - meet the SPARK complex! ✨
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process.
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Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes!
www.biorxiv.org/content/10.6...
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
Do you know an outstanding aquarist?
We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3
[Pls repost!]
Want to find out how a zebrafish develops from a small ball of cells into a functioning organism? 🐠 Then join us at the microscopes this Friday at @viennabiocenter.bsky.social for the Long Night of Research 🔬👩🔬
langenachtderforschung.at/station/592
📍Vienna BioCenter, 1030 Wien
⏰ 17:00-23:00