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New preprint by my former colleagues in the Pauli lab 🫶 When I first joined the lab, I naively thought Bouncer’s interacting partner was a single protein. Years later, it turns out that at least 7 components on the sperm side may mediate fertilization - meet the SPARK complex! ✨

New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇