Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.
We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.
Thread + link below.
Kenneth Loi
📢 Registration for our International Symposium on “New Concepts in Prokaryotic Virus-Host Interactions” is now open!
🗓️ 5–7 October 2026
📍 Harnack House, Berlin, Germany
➡️ Information and registration: spp2330.de/symposium-20...
Phages invented sgRNAs before humans!! 🧬
Obviously, for mischief… 😈
Loved seeing this story unfold!
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
New Concepts in Prokaryotic Virus-Host Interaction
Our lab website is finally online! pacesalab.com
You can find information about our research, publications, and on-going developments in the lab.
Phage receptor-binding proteins are known for their LEGO-like modularity, but we still do not fully understand their evolutionary potential and how it shapes phage host range. Our new preprint examines this systematically in Klebsiella phages. 🔗 www.biorxiv.org/content/10.6...
Thread 🧵
Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity. Aaron Whiteley
Alex Gao
Und das ganze Auditorium schweigt...wir müssen nochmal über Zivilcourage reden.
twp.ai
Use the Phage ORFeome Library to uncover the triggers responsible for immune activation.
Schmierereien mit Mordaufrufen, Störungen in Seminaren und wachsender Druck: Die Marburger Historikerin Christina Brüning spricht erstmals öffentlich über Bedrohungen gegen sie, warum sie sich an ihre...
