Research Professor & Group Leader at Vilnius University, LSC-EMBL - CRISPR, Gene Editing and Microbiology
Patrick Pausch
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Our lab website is finally online! pacesalab.com
You can find information about our research, publications, and on-going developments in the lab.
📢 Registration for our International Symposium on “New Concepts in Prokaryotic Virus-Host Interactions” is now open!
🗓️ 5–7 October 2026
📍 Harnack House, Berlin, Germany
➡️ Information and registration: spp2330.de/symposium-20...
Polish phage science meets Polish visual storytelling 🇵🇱🦠
To celebrate our last paper, we collaborated with an artist who previously worked on The Witcher 3 — to create a comic about phages and why understanding them matters in the fight against antibiotic-resistant bacteria.
Comic below 👇
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.
We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.
Thread + link below.
Bacteriophages are in a constant arms race with bacteria 🦠 The Phage ORFeome pooled library from the Aaron Whiteley lab contains phage proteins that activate antiphage defense systems — a tool to dissect the mechanisms of bacterial immunity. Aaron Whiteley
Und das ganze Auditorium schweigt...wir müssen nochmal über Zivilcourage reden.
Phage receptor-binding proteins are known for their LEGO-like modularity, but we still do not fully understand their evolutionary potential and how it shapes phage host range. Our new preprint examines this systematically in Klebsiella phages. 🔗 www.biorxiv.org/content/10.6...
Thread 🧵
Phages invented sgRNAs before humans!! 🧬
Obviously, for mischief… 😈
Loved seeing this story unfold!
Thrilled to share a major milestone from our long-running collaboration with Zuzanna Drulis-Kawa's lab in Wrocław — DepoCatalog, is now out in @natcomms.nature.com: 129 Klebsiella phage depolymerases, 75 capsule types, 5-class structural framework and public database.
www.nature.com/articles/s41...
Excited to share our new findings in @science.org on how the DRT3 bacterial defense system uses a reverse transcriptase that builds DNA repeats without a nucleic acid template. Microbes never cease to amaze!
www.science.org/doi/10.1126/...
Use the Phage ORFeome Library to uncover the triggers responsible for immune activation.
Schmierereien mit Mordaufrufen, Störungen in Seminaren und wachsender Druck: Die Marburger Historikerin Christina Brüning spricht erstmals öffentlich über Bedrohungen gegen sie, warum sie sich an ihre...
