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by @jimpick.com
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Such a fun collaboration with @michaelnadbio.bsky.social! Check out the latest form of #ubiquitin modification- MARUbylation!
Feb 26, 2025
Jonathan Pruneda
I'm super excited to share our study in collaboration with @jnpruneda.bsky.social, published today in @embojournal.org! We show that PARPs are modified with a non-canonical ester-linked mono-ADP-ribosylated ubiquitin species for the first time in cells: www.embopress.org/doi/full/10....
Feb 25, 2025
www.embopress.org
imageimageCertain E3 ligases have been found to ubiquitylate hydroxyl groups on free NAD+ and ADP-ribose in vitro, but the in vivo occurrence of this dual post-translational modification has remained ...
Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose | The EMBO Journal
Mike Cohen