Chronic inflammation has long been linked to cancer, but how is that history retained in the tissue?
In a new #Nature study, Nagaraja et al show that colitis leaves a lasting epigenetic memory in colonic stem cells, which persists after inflammation resolves & primes for subsequent tumor growth š§Ŗš¬
Marco et al. sought to expand the utility of immunizing radiation (IR) therapy by intratumorally delivering agents to remodel the tumor immune microenvironment (TIME). bit.ly/4t8ud0W
š¢ Tune in to this week's episode!
Dr. Alfred Singer at the National Cancer Institute Center for Cancer Research discusses his pioneering work on thymus development and T cell differentiation, including how T cells are selected to become CD4 helper or CD8 cytotoxic cells.
š§ https://bit.ly/4f2ci85
Thanks @the-node.bsky.social @biologists.bsky.social for allowing spreading the word
@kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social
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Reminder for the 51st Annual Meeting of the Scandinavian Society for Immunology!
The meeting will take place September 7-10, 2026 in Bergen and includes a summer school program
Early bird registration & abstract submission deadline: June 1st
For full program and to register: www.ssi2026.no
New piece on the decision of #ERC to reverse their stricter rules after the community came together to voice our opinions - a great example of the power of collective action!
Very happy to have been part of this - and to see how we can now build on this momentum š
www.nature.com/articles/d41... š§Ŗ
Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models - @mitkochinstitute.bsky.social go.nature.com/42td2fh
Very cool paper in @cp-immunity.bsky.social showing that a "dietary modulation of NKT-XCL1-cDC1 axis in combination with immune check points inhibitors may open avenues for improved treatments of colon cancer".š
www.sciencedirect.com/science/arti...
Video
The School will be aĀ 4-day (23-26 June 2026) Theory&Computation courseĀ in aĀ splendid Swedish inlandĀ ResortĀ (2 hours away from Stockholm - our bus will
thenode.biologists.com
Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation.
Immune-remodeling mRNAs delivered in lipid nanoparticles boost antitumor immunity.
go.nature.com
The efficacy of immune checkpoint inhibitors (ICIs) in colon cancer (CC) is limited by the tolerogenic immune landscape of both the tumor and the inteā¦
