Unlocking the therapeutic potential of cellular mechanobiology
| Science Advances www.science.org/doi/10.1126/...
"Applications should be formatted as bullet points and will be capped at ~300 words." If this were widespread, I would be submitting SO MANY GRANTS. www.biswasfamilyfoundation.org/science/fast...
We produced three HIV VLP types with the same Gag protein shell but different envelopes:
• GagM + gp150
• GagM + gp140HA₂tr
• GagM + gp120HA₂
This allowed us to isolate the mechanical role of the envelope proteins.
#Virology #ProteinEngineering
Recently published: PhD work of @leekruse.bsky.social
Viruses don’t just interact with cells biochemically — their mechanical properties also matter. We asked how modifying envelope proteins change stiffness and strength of HIV virus‑like particles (VLPs).
www.sciencedirect.com/science/arti...
Why it matters: VLP mechanics influence stability, entry, and vaccine performance. Envelope modifications may allow us to mechanically engineer VLPs, adding a new dimension to vaccine design.
#VaccineResearch #Bioengineering #Virology #ProteinEngineering
@uct-fhs-research.bsky.social