We study pathogen, cell & tissue mechanobiology in cardiac diseases and cancers ~ Team from Cameroon, Eswatini, South Africa & Uganda.
mechanobiology.uct.ac.za
Mechanobiology @ UCT
Loading...
Recently published: PhD work of @leekruse.bsky.social
Viruses don’t just interact with cells biochemically — their mechanical properties also matter. We asked how modifying envelope proteins change stiffness and strength of HIV virus‑like particles (VLPs).
www.sciencedirect.com/science/arti...
Using atomic force microscopy, we measured spring constant, breaking forces & deformation of VLPs.
Key result: VLPs containing influenza HA₂ sequences were mechanically stiffer and stronger than gp150 VLPs.
#AFM #Biophysics #Mechanobiology
Welcome to our new Master's student Moegamad Jack. With background in biology, he will study the #mechanobiology of #melanoma progression with supervisor Ghodeejah Higgins. #cancer #biophysics @uct-fhs-research.bsky.social
We produced three HIV VLP types with the same Gag protein shell but different envelopes:
• GagM + gp150
• GagM + gp140HA₂tr
• GagM + gp120HA₂
This allowed us to isolate the mechanical role of the envelope proteins.
#Virology #ProteinEngineering
www.linkedin.com/posts/explor...
Why it matters: VLP mechanics influence stability, entry, and vaccine performance. Envelope modifications may allow us to mechanically engineer VLPs, adding a new dimension to vaccine design.
#VaccineResearch #Bioengineering #Virology #ProteinEngineering
@uct-fhs-research.bsky.social
www.linkedin.com/posts/cmbbe-...
Mechanobiology @ UCT
The heart’s constant beating may actively suppress tumor growth in cardiac tissues, a new Science study reports.
The results shed light on the role of mechanical forces in protecting the heart from cancer and may pave the way to new cancer therapies. https://scim.ag/42xU4DX
Mechanobiology @ UCT
Mechanobiology @ UCT
Mechanobiology @ UCT
Mechanobiology @ UCT
Unlocking the therapeutic potential of cellular mechanobiology
| Science Advances www.science.org/doi/10.1126/...
Mechanobiology @ UCT
"Applications should be formatted as bullet points and will be capped at ~300 words." If this were widespread, I would be submitting SO MANY GRANTS. www.biswasfamilyfoundation.org/science/fast...
