TIR domains across diverse eukaryotes are enzymatically active. Especially interesting is the human TLR4 TIR, long thought to be enzymatically inactive, now shown to be catalytically active and to produce cADPR, a molecule involved in immunity across domains of life. Congrats, Bohdana!!
Honored to be part of the 2026 cohort and looking forward to the journey ahead! @schmidtfellows.bsky.social
Thank you! 🙏
The plot thickens! Exciting new discoveries in the NAD⁺ centric battlefield between bacteria and phages. Congrats, Ilya!
Preprint: Systematic discovery of TIR-based immune signaling systems in bacteria
Conservation of TIR-derived signals accross the tree of life! We found bacterial TIR immune systems that signal via canonical cADPR (like in humans) and 2'cADPR (a plant immune signal).
Documented 11 Thoeris types
A massive expansion of Thoeris defense systems !
Congrats @erezyirmiya.bsky.social and @soreklab.bsky.social
Thank you Jens!
New Thoeris systems and new bacterial TIRs, this time also producing plant and human immune signals 2'cADPR and cADPR!!! Congratulations to @erezyirmiya.bsky.social and Azita Leavitt! It was a pleasure to be involved in this project.
New Thoeris systems reveal a deep connection between bacterial TIR-produced immune signals to plant and human immunity🦠🌱🧍♀️
It was a great honor to contribute to this project! Congratulations to @erezyirmiya.bsky.social and Azita Leavitt!!🎉🥂
Incredible to learn how far-reaching and diverse Thoeris really is! TIRs play key roles across kingdoms, and this work beautifully highlights their bacterial origins.
Congrats @erezyirmiya.bsky.social & Azita! 👏🌟