TIR domains across diverse eukaryotes are enzymatically active. Especially interesting is the human TLR4 TIR, long thought to be enzymatically inactive, now shown to be catalytically active and to produce cADPR, a molecule involved in immunity across domains of life. Congrats, Bohdana!!
Erez Yirmiya
🎉Excited to share our new preprint!
TIR domains from diverse animals, including human TLR4, are catalytically active and produce cyclic ADP-ribose (cADPR). This enzymatic activity is widespread in animals and conserved across the tree of life.
www.biorxiv.org/content/10.6...
