My first-author PhD paper is out in @natcomms.nature.com 🙌 We developed unique in vivo/ex vivo live-imaging pipelines to uncover new muscle stem cell behaviors in #DuchenneMuscularDystrophy.
Big thanks to all co-authors & the @tajbakhshlab.bsky.social lab!
www.nature.com/articles/s41...
A work that took years to implement several quantitative live imaging pipelines. Worth the wait!! Beautiful results that give new insights into normal and dystrophic myogenic cell behavior and their dialogue with the niche. Kudos Liza, Brendan and colleagues.
Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...
🔬This paper explores the role of the primary cilium in neuronal migration. Using live-imaging, this study demonstrates the mechanosensory function of GPR161 receptor and its role on the cAMP/PKA signaling pathway, which in turn regulates the organization of the microtubule cage around the nucleus.
