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Ph.D Stem Cells and Regenerative Medicine @TajbakhshLab.bsky.social @pasteur.fr
Liza Sarde
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My first-author PhD paper is out in @natcomms.nature.com 🙌 We developed unique in vivo/ex vivo live-imaging pipelines to uncover new muscle stem cell behaviors in #DuchenneMuscularDystrophy. Big thanks to all co-authors & the @tajbakhshlab.bsky.social lab! www.nature.com/articles/s41...
🔬This paper explores the role of the primary cilium in neuronal migration. Using live-imaging, this study demonstrates the mechanosensory function of GPR161 receptor and its role on the cAMP/PKA signaling pathway, which in turn regulates the organization of the microtubule cage around the nucleus.
Our work investigates the dynamics of muscle stem cells in DMD pathology. We demonstrate stem cell migration impairment (fibre dependent) and premature differentiation driven by unbalanced symmetric divisions (fibre independent, regulated by Pi3K/Akt and p38)🎥💪🐭