Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Excited to see this work published online at @cp-cell.bsky.social today!
www.cell.com/cell/fulltex...
Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...
Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall?
Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬
Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und
doi.org
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
In the June 12th issue of Cell, Baluapuri et al. report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early and late consequences of INT depletion, the study exemplifies how transcriptional dysregulation can culminate in profound physiological outcomes.
CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase
to enable the selective and directional retrieval of polyubiquitinated proteins from
cilia, a process essential for m...
Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for termination, preventing immatur…
Integrator complex collapse: A mechanistic route to integrated stress response and disease
FN is taking a summer vacation 🏖️, but we'll be back in September with more exciting talks on chromatin and transcription!
If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...
How do cells keep their cilia “clean” and functional? Our new study uncovers a conserved mechanism for retrieving polyubiquitinated proteins from #cilia – a process essential for cellular signaling and health. #cellbiology #ciliopathy #ubiquitin #IFT 🧵👇 1/n
