Our collaborative paper with the Arndt lab is out today: doi.org/10.1093/nar/... (originally bioRxiv: www.biorxiv.org/content/10.1...). Here we asked the question of how CHD1 localizes to chromatin.
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
doi.org
Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...
Exciting new work from Apoorva Baluapuri of the Adelman lab! @baluapuri.bsky.social
@adelmanlab.bsky.social
www.sciencedirect.com/science/arti...
Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und
Integrator (INT) is a metazoan-specific complex that targets promoter-proximally paused RNA polymerase II (RNAPII) for termination, preventing immatur…www.sciencedirect.com
Excited to see this work published online at @cp-cell.bsky.social today!
www.cell.com/cell/fulltex...
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
Harvard Med BCMP
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.cell.com
www.nature.com
CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase
to enable the selective and directional retrieval of polyubiquitinated proteins from
cilia, a process essential for m...
Thrilled to see my work with @adelmanlab.bsky.social on INT/dsRNA highlighted by @willgarland.bsky.social and @heick.bsky.social ! Thanks for beautifully capturing how nuclear RNA guardians prevent cellular chaos. The ripple effects of transcriptional dysregulation are indeed profound! #RNABiology
Do you or someone you know have an exciting new chromatin/transcription story that you'll be ready to talk about in the Fall?
Then fill out or share this form to speak in the @fnucleosome.bsky.social seminar series! All models, organisms, and complexes welcome 🧬🧪🔬
Sven Lange
Tugce Aktas
In the June 12th issue of Cell, Baluapuri et al. report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early and late consequences of INT depletion, the study exemplifies how transcriptional dysregulation can culminate in profound physiological outcomes.
We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social.
Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
FN is taking a summer vacation 🏖️, but we'll be back in September with more exciting talks on chromatin and transcription!
If you've got a new story you'd like to share with the FN audience this fall, fill out the form here: docs.google.com/forms/d/e/1F...
Much appreciate the spotlight on our (@adelmanlab.bsky.social) paper about INT depletion/dsRNA-induced stress responses by @hanzlikovalab.bsky.social Amazing to see the finding being placed in perspective of the big picture of neurodevelopmental diseases and therapeutic targets 🙏 #RNABiology
Thank you for your interest in our seminar series!
We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
