Probabilistic machine learning to address questions in evolution and health #EvolutionaryMedicine. PI at the Centre for Genomic Regulation, co-leading a group with Mafalda Dias. Previously Harvard.
Jonathan Frazer
Very nice paper from Regeneron www.nature.com/articles/s41...
Mafalda has been shortlisted for the 2026 Premio Vanguardia de la Ciencia, one of the more visible science prizes in Spain.
Her interview: www.lavanguardia.com/vanguardia-d...
...and we would be very grateful if you could vote here: www.lavanguardia.com/vanguardia-d...
AI drug discovery has a data problem. We're fixing it.
At ALLOX, we've spent the last few years building something that didn't exist before: a platform that systematically maps functional hotspots at scale, measuring the effects of mutations on protein-protein interactions across the proteome.
The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...
🔗 doi.org/10.64898/202...
How much does a language model forget when finetuned on new tasks? We show both model size and optimization matter and forgetting can be nearly eliminated with self-generated replay!
arxiv.org/abs/2605.26097
w/Martin Marek, Dongkyu Cho, Shikai Qiu, Rumi Chunara, and Pavel Izmailov. 1/8
🧬 What if reading a tumor's mutations could tell us exactly how to fight it? Dr. @nlbigas.bsky.social is doing exactly that — decoding the genomic fingerprints of #cancer to guide personalized treatments. This is #CancerResearch, reimagined.
🚨 NEW
@FraticelliLab
PREPRINT JUST WENT LIVE
biorxiv.org/content/10.6...
Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!
New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/
www.biorxiv.org/content/10.6...
Join us for our next Kipoi Seminar with Noor Youssef, Harvard Medical School
@harvardmed.bsky.social
@deboramarks.bsky.social
👉 Predicting Viral Evolution to Accelerate Vaccine and Therapeutic Design
🧬 Wed May 6, 5:30pm CET
🍃http://kipoi.org/seminar
🦋 @kipoizoo.bsky.social
Meet evedesign: open-source AI, accessible protein design
✅Combine models for multiobjective optimization
✅Integrate experimental data
✅ Run on your own infrastructure
📄Paper: www.biorxiv.org/content/10.6...
💻Code: github.com/evedesignbio
🌐Webserver: evedesign.bio
Collaborate: [email protected]
Jonathan Frazer
Jonathan Frazer
www.biorxiv.org
ALLOX
Julia Rühle
Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.
