How much does a language model forget when finetuned on new tasks? We show both model size and optimization matter and forgetting can be nearly eliminated with self-generated replay!
arxiv.org/abs/2605.26097
w/Martin Marek, Dongkyu Cho, Shikai Qiu, Rumi Chunara, and Pavel Izmailov. 1/8
Andrew Gordon Wilson
Meet evedesign: open-source AI, accessible protein design
✅Combine models for multiobjective optimization
✅Integrate experimental data
✅ Run on your own infrastructure
📄Paper: www.biorxiv.org/content/10.6...
💻Code: github.com/evedesignbio
🌐Webserver: evedesign.bio
Collaborate: [email protected]
🚨 NEW
@FraticelliLab
PREPRINT JUST WENT LIVE
biorxiv.org/content/10.6...
Here, we describe PLSTCs, Soluplus-based expansion cultures of primary mouse *Acute Myeloid Leukemia* Stem Cells. And then we use LARRY barcoding to identify drivers of leukemogenicity and drug resistance!
Very nice paper from Regeneron www.nature.com/articles/s41...
New paper showing that much of the apparent success of protein language models in predicting mutational effects is a mirage: These models mostly memorize sites. 1/
www.biorxiv.org/content/10.6...
Unified protein design for computational researchers and experimentalists
AI drug discovery has a data problem. We're fixing it.
At ALLOX, we've spent the last few years building something that didn't exist before: a platform that systematically maps functional hotspots at scale, measuring the effects of mutations on protein-protein interactions across the proteome.
Debora Marks
The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...
🔗 doi.org/10.64898/202...
Mafalda has been shortlisted for the 2026 Premio Vanguardia de la Ciencia, one of the more visible science prizes in Spain.
Her interview: www.lavanguardia.com/vanguardia-d...
...and we would be very grateful if you could vote here: www.lavanguardia.com/vanguardia-d...
🧬 What if reading a tumor's mutations could tell us exactly how to fight it? Dr. @nlbigas.bsky.social is doing exactly that — decoding the genomic fingerprints of #cancer to guide personalized treatments. This is #CancerResearch, reimagined.
Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.
Join us for our next Kipoi Seminar with Noor Youssef, Harvard Medical School
@harvardmed.bsky.social
@deboramarks.bsky.social
👉 Predicting Viral Evolution to Accelerate Vaccine and Therapeutic Design
🧬 Wed May 6, 5:30pm CET
🍃http://kipoi.org/seminar
🦋 @kipoizoo.bsky.social
