End-to-end differentiable homology search for protein fitness prediction.
@yaringal.bsky.social @deboramarks.bsky.social @pascalnotin.bsky.social
arxiv.org/abs/2506.089...
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✅Combine models for multiobjective optimization
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📄Paper: www.biorxiv.org/content/10.6...
💻Code: github.com/evedesignbio
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Unified protein design for computational researchers and experimentalists
deboramarkslab.substack.com
Debora Marks
Kevin K. Yang 楊凱筌
This, by Michael Lynch.
I'd include AI techbros as well.
www.pnas.org/doi/10.1073/...
Weekly: Great papers across the centuries and subjects! Relaxing!
fermatslibrary.com/journal_club
Which RNAs are functional? Been a long time goal of @deboramarks.bsky.social to start an RNA sequence —> function and structure mapping.
Huge thx to team for pushing on this when - led by Rohit Arora and Murphy Angelo for seeing this thru and Pascal Notin for pulling together!!!
Try it! Give feedback -and be kind, it's beta ...
New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K
popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:
RNA, RNA, RNA -> RNAGym!
read all about it! biorxiv.org/content/10.110…
Been a long time goal of @deboramarks.bsky.social We tried a million years ago,
sciencedirect.com/science/articl���
Now total refresh led by Rohit Arora and Murphy Angelo and Pascal Notin for pulling together!!
My new paper "Deep Learning is Not So Mysterious or Different": arxiv.org/abs/2503.02113. Generalization behaviours in deep learning can be intuitively understood through a notion of soft inductive biases, and formally characterized with countable hypothesis bounds! 1/12
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End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon.
🌐 evedesign.bio
🚨 New paper 🚨 RNA modeling just got its own Gym! 🏋️ Introducing RNAGym, large-scale benchmarks for RNA fitness and structure prediction.
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