Cell Stem Cell publishes research and reviews at the forefront of stem cell biology, bioengineering, and regenerative medicine. Posts by Cell Stem Cell editors.
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Ketone bodies as guardians of leukemic stemness through ferroptosis suppression
Closing the gap: Toward functional, bioengineered esophageal grafts
Online Now! SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues #stemcells
Online Now! Designing complex organoids through developmental principles #stemcells
Human adrenal cortex organoids unlock new frontiers in development, disease, and regenerative therapy
Online Now! Generation of human appetite-regulating neurons and tanycytes from pluripotent stem cells #stemcells
There's still time to submit your abstract for the @cellpressevents.bsky.social #CSAging2026. Abstract deadline extended until June 26.
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Beyond replacement: Immature neurons as resilience partners in the aging hippocampus
Smooth muscle cells transiently acquire a CD34+ progenitor state upon injury to drive pathological vascular remodeling
Ferroptosis susceptibility in hippocampal neural precursor cells influences neurogenesis and memory across aging
Jia et al. develop SPACE-seq, a versatile technology that integrates CRISPR barcoding with spatial transcriptomics to jointly map cell ancestry, identity, and location. Compatible with diverse spatial platforms, SPACE-seq can be applied to a wide range of biological questions, revealing clonal architecture, migration, and fate-shaping interactions in development and cancer.
Brassard and Wells discuss how next-generation human pluripotent stem cell-derived organoids are achieving greater cellular complexity by more faithfully reproducing developmental processes. Advances in tissue interactions, specialized cell incorporation, and bioengineering technologies are enabling increasingly physiologically relevant organoid models to study human development, disease mechanisms, and regenerative biology.
Whether new neurons contribute to human cognition in old age remains debated. Recently in Cell Stem Cell, Tosoni et al. show that immature-neuron transcriptional programs persist in the aged dentate gyrus and that their molecular state, not simply their abundance, tracks Alzheimer’s pathology and cognitive resilience.
Walker and colleagues show that hippocampal neural precursor cells are especially vulnerable to ferroptosis-related stress. Modulating this pathway alters adult neurogenesis and spatial learning and memory, highlighting a potentially druggable mechanism to counter age-related cognitive decline.
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Lu et al. identify a smooth muscle-derived CD34⁺ transient progenitor cell (STPC) population that emerges following vascular injury. These cells exhibit high proliferative capacity and significantly contribute to neointimal hyperplasia, establishing STPCs as a potential therapeutic target for vascular diseases.
Abay-Nørgaard, Mueller, Hänninen, et al. generate cultures of the hypothalamic arcuate nucleus from hPSCs. They show transcriptional similarity to human ARC and response to appetite-regulating cues. BMP duration regulates ARC versus neighboring VMH fate and reveals the identification of divergent in vitro satiety-promoting POMC neurons of arcuate and non-arcuate origin.
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In a recent Nature Biotechnology paper, Pablo De Coppi et al. integrate tissue engineering with organ transplantation in a porcine model. They demonstrate that microinjection of autologous myogenic precursors and fibroblasts into a decellularized porcine scaffold, followed by bioreactor maturation, yields a graft that functionally integrates with the native esophagus.
Recent studies by Mayama et al. and Akkerman et al. established human adrenal cortex organoids that recapitulate fetal and adult adrenal development, offering unprecedented insight into differentiation pathways and allowing disease modeling. Though challenges like immature phenotypes and immune rejection will need addressing, they offer great potential for cell-based therapies.
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Leukemia stem cells exploit cell-intrinsic ketogenesis to suppress ferroptosis and sustain disease propagation. In this issue, Han et al. uncover a β-hydroxybutyrate-epigenetic-lipid remodeling axis that protects stemness by restraining ferroptosis, revealing a metabolic vulnerability with therapeutic potential.
