4/ We propose that this conserved architecture reveals a strategy for metabolic compartmentalization that couples efficient catalysis with increased molecular robustness.
3/ Structure-guided perturbation abolishes the assembly in vivo without measurably altering intrinsic catalytic activity, suggesting that the main role of the assembly is spatial organization rather than allosteric regulation.
2/ Urate oxidase homotetramers assemble into helical fibers that laterally tile into a stable, porous lamellar scaffold. This organization preserves accessible surface area while allowing substrate and product exchange.
Preprint with new server~ Using in situ cryo-ET, we identify a previously uncharacterized higher-order architecture of urate oxidase in mouse liver.
langtaosha.org.cn/lts/en/prepr...
It is exciting to see closely related biology highlighted in a recent Science paper as well, underscoring the importance of this field. science.org/doi/10.1126/...
The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...
Excited to share what we uncovered using in-tissue cryo-ET in mouse liver: a structural snapshot of lipid droplet biogenesis in situ. Timely reading—particularly after a lipid-rich Chinese New Year😂 The lipid homeostasis story governed by CLCC1 with more details here: www.nature.com/articles/s41...
Excited to share our new study:
rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...
How do cells trigger an antiviral response so quickly? 🤔 Our new paper proposes an "Intermitochondrial Activation" model. By visualizing MAVS with Cryo-ET, we saw that activated mitochondria use MAVS fibrils to "fish" for dormant mitochondria, spreading the alarm signal fast. doi.org/10.1038/s414...
But it’s self-limiting! We found that fibrils "stuck" between mitochondria are inaccessible to downstream signaling proteins (IRF3/TBK1), preventing immune overactivation. A perfect structural control mechanism. #TEAMTOMO #Immunology #Mitochondria
www.biorxiv.org
Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...
science.org
Abstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud
The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...
Excited to share our new study:
rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...
