How do cells trigger an antiviral response so quickly? 🤔 Our new paper proposes an "Intermitochondrial Activation" model. By visualizing MAVS with Cryo-ET, we saw that activated mitochondria use MAVS fibrils to "fish" for dormant mitochondria, spreading the alarm signal fast. doi.org/10.1038/s414...
Cellular & Molecular Immunology - Prion-like MAVS fibrils stitch mitochondria to promote a rapid antiviral response
