PhD Candidate in the Pritchard Lab at Stanford University. Interested in statistical and population genetics.
https://nikhilmilind.dev/
Nikhil Milind
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Excited to be at #PEQG26! I have a poster tonight on measuring selection on intraspecies variation in large microbial communities (415W), would love to hear what folks think!
#PEQG26 folks! I will be presenting my postdoc project with @jkpritch.bsky.social and @jeffspence.github.io about inferring population structure dynamics over time with tensor decomposition on ARG. The talk will be at the James Crow Talk session on Wednesday. Look forward to seeing everyone there!
@nature.com on Egli's human embryos base editing. www.nature.com/articles/d41... Quotes me on worries about risky efforts. Egli says that would be premature; yes, that's my point. I also agree w/Fyodor Urnov's that preimplantation testing is (almost always) a better solution even if this proves safe
🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities.
www.biorxiv.org/content/10.6...
We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...
The ‘base editing’ technique that researchers used is far from ready for the clinic, but critics worry that it will spur a rush to commercialize the approach.
Combined Optical Pooled Screens and Perturb-seq!
Great new work by Romain Lopez & Taka Kudo. This is one of a series of papers from our lab (here, with Aviv Regev) using perturbations to interpret human genetics; a key revelation for me is how transferable the mouse perturbs are to human genetics.
Romain Lopez
Our new paper doi.org/10.1098/rspb... on long-term genetic threats to small populations finds that "mutational meltdown" (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass.bsky.social @uliseshmc.bsky.social @jeremyjberg.bsky.social 1/5
🚀 We are introducing PerturbPair (with Taka Kudo) — a platform that combines parallel Perturb-seq and optical pooled screening (PerturbView) in primary cells to systematically map at massive scale how genetic perturbations reshape cellular states across modalities.
www.biorxiv.org/content/10.6...
Pareto curves in track racing:
So, this weekend I was playing around in Claude Code with a database of track times (all Diamond Leagues and global champs from last 12 years).
I really like this viz of tactics in the men's 5000m, one of the most tactical events in track.
Abstract. Habitat loss contributes to extinction risk in multiple ways. Genetically, small populations can face an ‘extinction vortex’—a positive feedback
