🦠🧪🧬 Excited to share that our GPS Pipeline, the portable and scalable genomic pipeline for Streptococcus pneumoniae surveillance, is now published in @natcomms.nature.com
🔗 nature.com/articles/s41... #GPS_project
[🚨New Paper 🚨]SeroBA recognised 102/107 known pneumococcal serotypes and its companion resources webpage SeroBAnk are now published on Microbial Genomics @microbiologysociety.org
www.microbiologyresearch.org/content/jour...
It's likely the next pandemic will come from wildlife. But how can we prepare for the next spillover event, if we don't understand the diversity of viruses out there? 🦔🦠
Check out our Genomewatch article, where we discuss using meta-genomics to study viral diversity in wild mammals 🖥️🧬
rdcu.be/eHIBl
[🚨Data release🚨] The #GPS_project database Monocle is now having 40k pneumococcal genomes and detailed metadata !
Thanks @HarryHung at @sangerinstitute and Simran Utreja at CDC to put them together!
data-viewer.monocle.sanger.ac.uk/project/gps
[New pre-print🚨] When a single genotype (pbp) confer resistance (penicillin, amoxicillin, cephalosporins) to multiple antibiotics, how do we make sense of genetic changes and their impact on AMR?
A new concept - AMR cartography is invented.
www.biorxiv.org/content/10.1...
A great collaboration with Dr Dan Neill and his team at University of Dundee and scientists from UCL, St. Jude Children's Research Hospital, Uni of Bern, Uni of Liverpool, Uni of Cape Town, Uni of Western Australia, Uni of Bath, Milner centre for Evolution and @sangerinstitute.bsky.social
[New paper alert 🚨 ] What happens when pneumococci 'slip' and 'add' just one extra A in a promoter spacer of a sugar scavenging gene? 🧬
www.cell.com/cell-host-mi...
This tiny mutation—found not only mouse colonization models but also clinical isolates from the #GPS_project — enhance S. pneumoniae colonization reducing mucus trapping.
[🚨 New paper] The first nationwide, longitudinal WGS analysis of Streptococcus pneumoniae in Taiwan (2006–2022).
1,343 isolates from 27 hospitals, we track serotype, AMR, and genomic lineage before and after PCV13.
#GPS_project #PCV13_impact #Taiwan
www.microbiologyresearch.org/content/jour...
However, this promoter variant does not thrive on its own and is usually co-occurence of the wild-type promoter without "A", showing heterogeneous gene expression during single infections provides population benefits.